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KMID : 0811719990030030245
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Korean Journal of Physiology & Pharmacology
1999 Volume.3 No. 3 p.245 ~ p.250
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Electroencephalographic Effects of Chlorpromazine in Rats
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Jeong I Yun
Maan Gee Lee
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Abstract
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The effects of an antipsychotic, chlorpromazine, on the electroencephalogram (EEG) were observed while rats were awake but immobile. The time course and the dose-dependency of the EEG changes were examined. The method of the power spectrum analysis was used to examine the EEG changes by the drug. The bands were divided into delta
(
1
∼
3.5
H
z
)
,
theta
(
3.5
∼
8
H
z
)
,
alpha
(
8
∼
13
H
z
)
,
beta1
(
13
∼
21
H
z
)
,
beta2
(
21
∼
30
H
z
)
and gamma
(
30
∼
50
H
z
)
.
In rats, the low dose of chlropromazine (1 mg/kg, i.p.) produced a significant increase in the power of the beta1 band. The higher doses (5, 10 mg/kg, i.p.) produced a significant increase in the power of the delta, theta, alpha and beta1 bands, and the decrease in the power of the gamma band. The powers of the bands changed dose-dependently. Then, the authors discussed whether the EEG effects produced by a drug are associated with the accompanying behavioral changes specifically.
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KEYWORD
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Antipsychotic, Chlorpromazine, Electroencephalography, EEG, Power, Spectrum, Rat
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